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- Bioss
- bs-7736P
- 2025年10月16日
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500ug
| 产品编号 | bs-7736P |
| 英文名称 | ASB3 Antibody Blocking Peptide |
| 中文名称 | 锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3封闭多肽 |
| 英文别名 | Ankyrin repeat and SOCS box containing 3; Ankyrin repeat and SOCS box containing protein 3; Ankyrin repeat and SOCS box protein 3; ASB-3; ASB3; ASB3_HUMAN; Weakly similar to ankyrin brain variant 2. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Other Antibodies > Other Antibodies |
| 亚基 | Interacts with TCEB2 and TNFRSF1B. |
| 相似性 | Contains 11 ANK repeats. Contains 1 SOCS box domain. |
| 功能 | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the elongin B and C complex. Serveral other families of proteins also contain SOCS boxes but differ from the SOCS proteins in the type of domain they contained upstream of the SOCS box. Four members of the ankyrin repeat and SOCS box-containing (ASB) protein family are identified and termed as ASB-1, ASB-2, ASB-3 and ASB-4. ASB-1 is expressed in multiple organs, including the hematopoietic compartment. ASB-1 knock-out mice display a diminution of spermatogenesis with less complete filling of seminiferous tubules. Asb-2 is a novel retinoic-acid (RA)-induced gene in acute promyelocytic leukemia (APL) cells and its expression induces growth-inhibition and chromatin condensation recapitulating early events critical to RA-induced differentiaiton of APL cells. ASB-2 is directly induced by all-trans retinotic acid, by the binding of RARa to the RAR binding element/RXR binding element in the Asb-2 promoter. |
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ASB3 Antibody Blocking Peptide(bs-7736P)-500ug
￥880
