- ￥880
- Bioss
- bs-7733P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-7733P |
| 英文名称 | WAPL Antibody Blocking Peptide |
| 中文名称 | EBV核蛋白2/EBNA2封闭多肽 |
| 英文别名 | FOE; Friend of EBNA2 (Epstein Barr virus nuclear protein 2); Friend of EBNA2 protein; WAPAL; WAPL; WAPL_HUMAN; Wings apart like homolog; Wings apart like homolog (Drosophila); wings apart-like homolog; Wings apart-like protein homolog. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Cell Division > Chromatid Cohesion Epigenetics and Nuclear Signaling > Cell cycle > Chromosome Structure > Chromatid Cohesion |
| 亚基 | Interacts with the cohesin complex throughout the cell cycle; interacts with both chromatin-bound and soluble pools of the complex. Interacts with RAD21; the interaction is direct. Interacts with PDS5A; the interaction is direct, cohesin-dependent and competitive with SORORIN. Interacts (via FGF motifs) with PDS5B; the interaction is direct. Interacts with SMC3. Isoform 2 interacts with Epstein-Barr virus EBNA2. |
| 亚细胞定位 | Nucleus and Nucleus. Chromosome. Cytoplasm. Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase. |
| 组织特异性 | Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart. |
| 相似性 | Contains 1 WAPL domain. |
| 功能 | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.Tissue specificity: Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart. |
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WAPL Antibody Blocking Peptide(bs-7733P)-500ug
￥880
