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- Bioss
- bs-7729P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-7729P |
| 英文名称 | SMC5 Antibody Blocking Peptide |
| 中文名称 | 染色体结构维持蛋白5封闭多肽 |
| 英文别名 | hSMC 5; hSMC5; SMC 5 SMC 5 structural maintenance of chromosomes 5 like 1 SMC5 L1 SMC5 protein SMC5 structural maintenance of chromosomes 5 like 1 SMC5L1 Structural maintenance of chromosomes 5 like 1 Structural maintenance of chromosomes protein 5; SMC5_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Cell Division > Chromatid Cohesion Epigenetics and Nuclear Signaling > Cell cycle > Chromosome Structure > Chromatid Cohesion Epigenetics and Nuclear Signaling > Chromosome Structure > Cohesins |
| 亚基 | Forms a heterodimer with SMC6. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2. |
| 亚细胞定位 | Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines. |
| 组织特异性 | Widely expressed. |
| 翻译后修饰 | Ubiquitinated. |
| 相似性 | Belongs to the SMC family. SMC5 subfamily. |
| 功能 | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics. |
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SMC5 Antibody Blocking Peptide(bs-7729P)-500ug
￥880
