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- Bioss
- bs-9038P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9038P |
| 英文名称 | FRMPD2 Antibody Blocking Peptide |
| 中文名称 | FRMPD2封闭多肽 |
| 英文别名 | FERM and PDZ domain containing protein 2; PDZ domain containing protein 4; PDZ domain containing protein 5C; PDZ domain containing 4 PDZD5C; PDZK4; PDZK5C;FRPD2_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Interacts (via the PDZ 2 domain) with CTNND2 (via the extreme C-terminus). Interacts (via the PDZ 2 domain) with PKP4 (via the extreme C-terminus); this interaction directed FRMPD2 to the basolateral membranes. Interacts (via the PDZ 2 domain) with ARVCF (via the extreme C-terminus). |
| 亚细胞定位 | Cytoplasm (Potential). Basolateral cell membrane. Cell junction, tight junction. Note=Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1. |
| 组织特异性 | Expressed in epithelial cells. |
| 相似性 | Contains 1 FERM domain. Contains 1 KIND domain. Contains 3 PDZ (DHR) domains. |
| 功能 | May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009] |
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FRMPD2 Antibody Blocking Peptide(bs-9038P)-500ug
￥880
