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- bs-7711P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-7711P |
| 英文名称 | PCNT Antibody Blocking Peptide |
| 中文名称 | 中心粒周蛋白封闭多肽 |
| 英文别名 | Centrosome Marker; Ken; Kendrin; KIAA0402; MOPD2; PCN; PCNT 2; PCNT B; PCNT1; PCNT2; PCNTB; PCTN2; Pericentrin 1; Pericentrin 1; Pericentrin 2; Pericentrin 380; Pericentrin B; SCKL4; PCNT_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with CHD3. Interacts with CHD4; the interaction regulates centrosome integrity (By similarity). Interacts with DISC1 and PCM1. Binds calmodulin. Interacts with CDK5RAP2; the interation is leading to centrosomal localization of PCNT and CDK5RAP2. Interacts with isoform 1 of NEK2. |
| 亚细胞定位 | Cytoplasm; cytoskeleton; centrosome. Note: Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome |
| 组织特异性 | Expressed in all tissues tested, including placenta, liver, kidney and thymus. |
| 功能 | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. [provided by RefSeq, Jul 2008]. |
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PCNT Antibody Blocking Peptide(bs-7711P)-500ug
￥880
