- ￥880
- Bioss
- bs-7644P
- 2025年10月16日
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500ug
| 产品编号 | bs-7644P |
| 英文名称 | RTN3 Antibody Blocking Peptide |
| 中文名称 | 神经内分泌特异性蛋白2封闭多肽 |
| 英文别名 | ASYIP; Neuroendocrine specific protein like 2; Neuroendocrine-specific protein-like 2; Neuroendocrine-specific protein-like II; NSP like protein II; NSP-like protein 2; NSP-like protein II; NSPL2; NSPLII; Reticulon 3; Reticulon-3; Reticulon3; Rtn3; RTN3_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis > Metabolism Cancer > Cell Death > Apoptosis > Mitochondrial Cell Biology > Apoptosis > Mitochondrial Metabolism > Pathways and Processes > Metabolism processes > Apoptosis Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers Signal Transduction > Protein Trafficking > ER Proteins Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation |
| 亚基 | Homodimer. Interacts with ATL1 (By similarity). Interacts with RTN4. Isoform 3 interacts with BACE1, BACE2, BCL2 and FADD. Interacts with Coxsackievirus A16, enterovirus 71 and poliovirus P2C proteins. Interacts with ATL2. |
| 亚细胞定位 | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. |
| 组织特异性 | Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma. |
| 相似性 | Contains 1 reticulon domain. |
| 功能 | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms. |
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RTN3 Antibody Blocking Peptide(bs-7644P)-500ug
￥880
