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- bs-7634P
- 2025年10月16日
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500ug
| 产品编号 | bs-7634P |
| 英文名称 | PARL Antibody Blocking Peptide |
| 中文名称 | 骨骼肌细胞线粒体膜蛋白PARL封闭多肽 |
| 英文别名 | Mitochondrial intramembrane cleaving protease PARL; Mitochondrial intramembrane-cleaving protease PARL; P-beta; parl; PARL_HUMAN; Pbeta; presenilin associated rhomboid-like; Presenilins associated rhomboid-like protein; PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis > Metabolism Cancer > Cell Death > Apoptosis > Mitochondrial Cell Biology > Apoptosis > Mitochondrial Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Other proteases Metabolism > Pathways and Processes > Metabolism processes > Apoptosis Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease > Proteases |
| 亚细胞定位 | Mitochondrion inner membrane and Nucleus. Translocated into the nucleus by an unknown mechanism. |
| 翻译后修饰 | P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated. |
| 相似性 | Belongs to the peptidase S54 family. |
| 功能 | Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Presenilins associated rhombiod-like protein (PARL) is a mitochondrial intramembrane-cleaving protease belonging to the S54 family of proteins. PARL is involved in intramembrane regulated proteolysis as its catalytic activity involves the cleaving of signaling proteins at intracellular membranes to release active fragments in signal transduction cascades. Using a triad of histidine, serine and asparagine, PARL cleaves type-1 transmembrane domains. PARL is a multi-pass membrane protein localizing to the inner and outer mitochondrial membranes, but it can also be detected in the nucleus following proteolytical processing of P-β. PARL co-localizes with the presenilins PSEN1 and PSEN2, the familial Alzheimer disease products. |
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PARL Antibody Blocking Peptide(bs-7634P)-500ug
￥880
