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- Bioss
- bs-8867P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-8867P |
| 英文名称 | GHRHR Antibody Blocking Peptide |
| 中文名称 | 生长激素释放因子受体封闭多肽 |
| 英文别名 | GHRFR; GHRH R; GHRH receptor; GHRHR_HUMAN; GHRHRpsv; GRF R; GRF receptor; GRFR; Growth hormone releasing factor receptor; Growth hormone releasing hormone receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing hormone receptor. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neuroendocrinology > GH Regulation Neuroscience > Neurotransmission > Receptors / Channels > GPCR > More GPCR |
| 亚细胞定位 | Cell membrane. |
| 组织特异性 | Pituitary gland. |
| 相似性 | Belongs to the G-protein coupled receptor 2 family. |
| 功能 | Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GHRH-R is a seven transmembrane domain protein that localizes to the somatotroph of the pituitary. GHRH-R plays an important role in growth and acts as a high-affinity receptor for GHRH. Binding of GHRH leads to the coupling of GHRH-R to G-protein which stimulates increased adenylyl cyclase activity and the accumulation of cAMP leading to the synthesis and release of growth hormone and somatotroph proliferation. In addition, this signalling pathway may have direct action in fetal/placental development, reproduction and immune function. GHRH and GHRH-R may also play a role in the regulation of non-rapid eye movement sleep (NREMS). The expression of GHRH-R is dependent on the presence of the POU domain factor Pit-1. Mutations in the gene encoding this protein can result in isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, and anterior pituitary hypoplasia (APH). |
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GHRHR Antibody Blocking Peptide(bs-8867P)-500ug
￥880
