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- Bioss
- bs-7627P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-7627P |
| 英文名称 | PCLAF Antibody Blocking Peptide |
| 中文名称 | 丙型肝炎病毒非结构蛋白5A反式激活蛋白9封闭多肽 |
| 英文别名 | L5 antibody PAF; HCV NS5A transactivated protein 9; Hepatitis C virus NS5A transactivated protein 9; NS5 ATP9; NS5ATP9; OEATC 1; Overexpressed in anaplastic thyroid carcinoma 1; p15(PAF); p15PAF; PCNA associated factor; PCNA-associated factor; PAF15_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis > Metabolism Cancer > Cell Death > Apoptosis > Mitochondrial Cancer > Cell Death > Apoptosis > Nucleus Cell Biology > Apoptosis > Mitochondrial Cell Biology > Apoptosis > Nucleus Metabolism > Pathways and Processes > Metabolism processes > Apoptosis Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers |
| 亚基 | Interacts (when monoubiquitinated at Lys-15 and Lys-24)with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1. |
| 亚细胞定位 | Nucleus. Cytoplasm, perinuclear region. |
| 组织特异性 | Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas and in non-small-cell lung cancer lines. |
| 翻译后修饰 | Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome. |
| 功能 | May be involved in protection of cells from UV-induced cell death. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | NS5ATP9/PAF/p15(PAF) is involved in protection of cells from UV-induced cell death and is also a Hepatitis C NS5A up-regulation gene which may play a role in the pathogenesis of HCV-associated hepatocellular carcinoma. |
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PCLAF Antibody Blocking Peptide(bs-7627P)-500ug
￥880
