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- Bioss
- bs-7618P
- 2025年10月16日
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500ug
| 产品编号 | bs-7618P |
| 英文名称 | NOC2L Antibody Blocking Peptide |
| 中文名称 | NOC2家族样蛋白封闭多肽 |
| 英文别名 | NIR; NOC2 like; Novel INHAT (inhibitor of histone acetyltransferase) repressor; Nucleolar complex associated 2 homolog (S. cerevisiae); Protein NOC2 homolog; NOC2L_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Apoptosis > Intracellular > p53 Pathway Epigenetics and Nuclear Signaling > Cell cycle > Cell Cycle Inhibitors > p53 Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HAT Epigenetics and Nuclear Signaling > Transcription > Co-factors Epigenetics and Nuclear Signaling > Transcription > Other factors |
| 亚基 | Interacts with p53/TP53. Interacts (via the N- and C-terminus domains) with AURKB (via the middle kinase domain). Interacts with TP63 isoform TA*-gamma (via activation domain). Interacts with histone H3 (via N-terminus and non-acetylated form preferentially). Associates with core histones and nucleosomes. |
| 亚细胞定位 | Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis. |
| 相似性 | Belongs to the NOC2 family. |
| 功能 | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | NOC2L is a transcriptional corepressor with inhibitor of histone acetyltransferase (INHAT) activity. NOC2L or NIR (Novel INHAT Repressor) is ubiquitously expressed throughout embryonic development and adulthood. It is a potent transcriptional corepressor that is not blocked by histone deacetylase inhibitors and is capable of silencing both basal and activator-driven transcription. NOC2L directly binds to nucleosomes and core histones and prevents acetylation by histone acetyltransferases, thus acting as a bona fide INHAT. |
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NOC2L Antibody Blocking Peptide(bs-7618P)-500ug
￥880
