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- Bioss
- bs-7600P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-7600P |
| 英文名称 | IKBIP Antibody Blocking Peptide |
| 中文名称 | IKK激酶相互作用蛋白封闭多肽 |
| 英文别名 | I kappa B kinase interacting protein; IKIP1; IKIP2; IKIP3; IKK interacting protein; IKIP_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis > Apoptosis Markers > NFkB > IKK Cell Biology > Apoptosis > Intracellular > NFkB > IKK Cell Biology > Apoptosis > Intracellular > p53 Pathway |
| 亚细胞定位 | Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization. |
| 组织特异性 | Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus and skeletal muscle. |
| 翻译后修饰 | Isoform 4 may be phosphorylated at Thr-362 by similarity with mouse isoform 1. N-glycosylated. Isoform 4 is glycosylated at Asn-154. |
| 功能 | Target of p53/TP53 with pro-apoptotic function. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | IKIP (I kappa B kinase interacting protein)is located on chromosome 12 in close proximity to APAF1 (apoptotic protease-activating factor-1). IKIP was originally cloned from a yeast two hybrid screening as an IKK2 interacting protein. IKIP and APAF1 share a common 488 bp promoter from which the two genes are transcribed in opposite directions, presumably in a co-regulated manner. Three IKIP transcripts are generated by differential splicing and alternative exon usage and show no significant homology to other genes. IKIP is expressed predominantly in the lung, kidney, spleen, thymus and skeletal muscle. Like APAF1, expression of IKIP is enhanced by irradiation, in a p53-dependent manner. When transfected into endothelial cells IKIP promotes apoptosis suggesting that it plays a role in the cell death process as well as NF-kB regulation. |
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IKBIP Antibody Blocking Peptide(bs-7600P)-500ug
￥880
