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- Bioss
- bs-20219P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-20219P |
| 英文名称 | KCND3 Antibody Blocking Peptide |
| 中文名称 | 离子通道蛋白Kv4.3封闭多肽 |
| 英文别名 | KCND 3; KCND 3L; KCND 3S; KCND3; KCND3L; KCND3S; KSHIVB; Kv 4.3; Potassium ioinic channel Kv4.3; Potassium voltage gated channel Shal related subfamily member 3; Potassium voltage gated channel subfamily D member 3; Sha1 related potassium channel Kv4.3; Voltage gated K+ channel; Voltage gated potassium channel Kv4.3; Voltage gated potassium channel subunit Kv4.3; KCND3_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Heart > Cardiac arrhythmias Neuroscience > Neurotransmission > Receptors / Channels > Potassium Channels |
| 亚基 | Homotetramer or heterotetramer with KCND1 and/or KCND2. Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Interacts with KCNE1, KCNE2, SCN1B and KCNAB1. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Cell projection, dendrite. |
| 组织特异性 | Highly expressed in brain, in particular in the retrosplenial cortex, medial habenula, anterior thalamus, hippocampus, cerebellum and lateral geniculate and superior colliculus. Highly expressed in heart atrium (at protein level) and throughout the ventricle wall, in lung and vas deferens. |
| 翻译后修饰 | Regulated through phosphorylation at Ser-569 by CaMK2D (By similarity). |
| 相似性 | Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. |
| 功能 | Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Voltage gated potassium (Kv) channels represent the most complex class of voltage gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence related potassium channel genes (shaker, shaw, shab, and shal) have been identified in Drosophila, and each has been shown to have human homologs. This protein is a member of the potassium channel, voltage gated, shal related subfamily, members of which form voltage activated A type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. |
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KCND3 Antibody Blocking Peptide(bs-20219P)-500ug
￥880
