- ￥880
- Bioss
- bs-7592P
- 2025年10月16日
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500ug
| 产品编号 | bs-7592P |
| 英文名称 | DARC/CD234 Antibody Blocking Peptide |
| 中文名称 | 非典型趋化因子受体1封闭多肽 |
| 英文别名 | ACKR1_MOUSE; Atypical chemokine receptor 1; Duffy antigen/chemokine receptor; CD234; Ackr1; Darc; Dfy; Fy; AA162249; CCBP1; ESTM35; GPD; atypical chemokine receptor 1 (Duffy blood group). |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Blood Cardiovascular > Blood > Blood Cell Antigens Immunology > Innate Immunity > Chemokines > Alpha Chemokine Rec. (CXCR) Immunology > Innate Immunity > Chemokines > Beta Chemokine Rec. (CCR) Microbiology > Organism > Eukaryotic Microorganism > Protozoa > Plasmodium Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. |
| 组织特异性 | Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily. |
| 功能 | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
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DARC/CD234 Antibody Blocking Peptide(bs-7592P)-500ug
￥880
