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- bs-7556P
- 2025年10月16日
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500ug
| 产品编号 | bs-7556P |
| 英文名称 | ALOX5AP Antibody Blocking Peptide |
| 中文名称 | 5脂氧合酶激活蛋白封闭多肽 |
| 英文别名 | 5-lipoxygenase activating protein; Arachidonate 5 lipoxygenase activating protein; 5-lipoxygenase activating protein; AL5AP_HUMAN; ALOX 5AP; ALOX5 AP; Arachidonate 5-lipoxygenase-activating protein; Five lipoxygenase activating protein; FLAP; MK 886 binding protein; MK-886-binding protein. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Atherosclerosis > Vascular Inflammation > Inflammatory mediators Immunology > Immune System Diseases > Allergens Immunology > Innate Immunity > Macrophage / Inflamm. Signal Transduction > Second Messenger > Lipid Messengers |
| 亚基 | Homotrimer. Interacts with LTC4S and ALOX5. |
| 亚细胞定位 | Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| 相似性 | Belongs to the MAPEG family. |
| 功能 | Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.Involvement in disease: Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) ; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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