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500ug
| 产品编号 | bs-7555P |
| 英文名称 | phospho-EPH A3+A4+A5 (Tyr779) Antibody Blocking Peptide |
| 中文名称 | 磷酸化内皮细胞受体蛋白酪氨酸激酶A3+A4+A5封闭多肽 |
| 英文别名 | EPH A3+A4+A5 (phospho Y779 + Y779 + Y833); EPH A3+A4+A5 (phospho Y779); p-EPH A3+A4+A5 (phospho Y779); CEK7; EHK 1; EHK1; EK4; EK7; EK8; EPH homology kinase 1; EPH like kinase 4; EPH like kinase 7; EPH like kinase 8; Eph like tyrosine kinase 1; EPH receptor A3; EPH receptor A4; EPH receptor A5; Ephrin type A receptor 3; Ephrin type A receptor 4; Ephrin type A receptor 5; ETK; ETK1; HEK; HEK4; HEK7; HEK8; Human embryo kinase 1; Receptor protein tyrosine kinase HEK7; Receptor protein tyrosine kinase HEK8; SEK; TYRO1; TYRO1 protein tyrosine kinase; TYRO4; TYRO4 protein tyrosine kinase; Tyrosine protein kinase receptor EHK 1; Tyrosine protein kinase receptor ETK1; Tyrosine protein kinase receptor SEK; Tyrosine protein kinase TYRO1; EPHA3_HUMAN; EPHA4_HUMAN; EPHA5_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases |
| 亚基 | Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3 signaling (By similarity). Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase activation. |
| 亚细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. |
| 组织特异性 | Widely expressed. Highest level in placenta. |
| 翻译后修饰 | Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1. |
| 相似性 | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 1 Eph LBD (Eph ligand-binding) domain. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain. |
| 功能 | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neiGHBoring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | EphA3 is a member of the Ephrin (Eph) family. The Ephrins and Eph-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the Ephrin A (EphA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the Ephrin B (EphB) class, which are transmembrane proteins. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. |
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phospho-EPH A3+A4+A5 (Tyr779) Antibody Blocking Peptide(bs-7555P)-500ug
￥1080
