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- Bioss
- bs-7549P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-7549P |
| 英文名称 | GAS 6 Antibody Blocking Peptide |
| 中文名称 | 生长停滞特异性蛋白6封闭多肽 |
| 英文别名 | AXL receptor tyrosine kinase ligand; AXL stimulatory factor; AXLLG; AXS F; AXSF; Gas 6; GAS6; Growth-arrest-specific protein 6; Growth-arrest-specific protein 6 precursor. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Atherosclerosis > Thrombosis Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases Stem Cells > Hematopoietic Progenitors > Myeloid > Thrombocytic Lineage Stem Cells > Mesenchymal Stem Cells > Chondrogenesis |
| 亚基 | Heterodimer and heterotetramer with AXL. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. |
| 翻译后修饰 | Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL. |
| 相似性 | Contains 4 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 2 laminin G-like domains. |
| 功能 | Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GAS 6 is a ligand for the tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS 6 regulates chondrogenic differentiation from mesenchymal cells and also plays a role in thrombosis by amplifying platelet aggregation and secretion in response to known agonists. It is over expressed in human gliomas and regulate the phagocytic function of sertoli cells. |
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GAS 6 Antibody Blocking Peptide(bs-7549P)-500ug
￥880
