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- Bioss
- bs-20049P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-20049P |
| 英文名称 | SCN4B Antibody Blocking Peptide |
| 中文名称 | 钠通道亚基β4封闭多肽 |
| 英文别名 | SCN4B_MOUSE; SCN4B_HUMAN; Sodium channel subunit beta-4. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neural Signal Transduction |
| 亚基 | The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Associates with SCN2A. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. |
| 翻译后修饰 | Contains a number of interchain disulfide bonds with SCN2A. |
| 相似性 | Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. |
| 功能 | Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009] |
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SCN4B Antibody Blocking Peptide(bs-20049P)-500ug
￥880
