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- Bioss
- bs-20045P
- 2025年10月16日
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500ug
| 产品编号 | bs-20045P |
| 英文名称 | CNOT4 Antibody Blocking Peptide |
| 中文名称 | 细胞表面趋化因子受体4相关蛋白4封闭多肽 |
| 英文别名 | CCR4 NOT transcription complex subunit 4; CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CLONE243; CNOT 4; Cnot4; CNOT4_HUMAN; E3 ubiquitin-protein ligase CNOT4; NOT 4; NOT4 (negative regulator of transcription 4 yeast) homolog; NOT4; NOT4H; Potential transcriptional repressor NOT4Hp. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > RING Finger E3 Ligase Epigenetics and Nuclear Signaling > Transcription > Other factors |
| 亚基 | Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Binds CNOT1 via its C-terminus. Binds E2 ubiquitin ligases via its RING domain. Interacts (via RING domain) with UBE2D2. |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 翻译后修饰 | Autoubiquitinated. |
| 相似性 | Contains 1 C3H1-type zinc finger.
Contains 1 RING-type zinc finger. Contains 1 RRM (RNA recognition motif) domain. |
| 功能 | Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits within the complex are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. CNOT4 (CCR4-NOT transcription complex subunit 4), also known as CCR4-associated factor 4 and E3 ubiquitin-protein ligase CNOT4, is a 575 amino acid protein that is a subunit of the CCR4-NOT complex. CNOT4 contains one C3H1-type zinc finger, one RING-type zinc finger and one RRM (RNA recognition motif) domain. Via its RING domain, CNOT4 binds E2 ubiquitin ligases. CNOT4 functions as a UbcH5B-dependent ubiquitin-protein ligase (E3 ligase). There are eight isoforms of CNOT4 that are expressed as a result of alternative splicing events. |
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CNOT4 Antibody Blocking Peptide(bs-20045P)-500ug
￥880
