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- Bioss
- bs-17655P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-17655P |
| 英文名称 | SPESP1 Antibody Blocking Peptide |
| 中文名称 | 精子赤道区域蛋白1封闭多肽 |
| 英文别名 | Equatorial segment protein; ESP; Glycosylated 38 kDa sperm protein C 7/8; Glycosylated 38 kDa sperm protein C-7/8; MGC24663; SP-ESP; Sperm equatorial segment protein 1; Sperm equatorial segment protein 1 precursor; SPESP; SPESP_HUMAN; Spesp1. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cytoplasmic vesicle > secretory vesicle > acrosome. Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome. |
| 组织特异性 | Highly expressed in testis, where it is localized in the acrosome of postmeiotic stages of spermiogenesis (round and elongating spermatids and in ejaculated spermatozoa) (at protein level). Poorly expressed in placenta and fetal lung. |
| 相似性 | Belongs to the SPESP1 family. |
| 功能 | The encoded protein is a human alloantigen involved in sperm-egg binding and fusion. [provided by RefSeq, Apr 2010] |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SPESP1 is a 399 amino acid protein belonging to the SPESP1 family. Localizing to cytoplasmic vesicle, secretory vesicle, and acrosome, SPESP1 is highly expressed in testis, with lower levels found in placenta and fetal lung. SPESP1 establishes an equatorial segment subcompartment early in sperm development and is required for proper sperm-egg fusion. Disruption of SPESP1 leads to abnormal distribution of sperm proteins resulting in a detached membrane from the equatorial segment and less fertile sperm. SPESP1 may interact with IZUMO1 and MN9 antigen and contains an N-glycosylation site as well as several cAMP-dependent kinase, protein kinase C, and casein kinase II consensus phosphorylation sites. |
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SPESP1 Antibody Blocking Peptide(bs-17655P)-500ug
￥880
