- ￥880
- Bioss
- bs-12542P
- 2025年10月16日
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500ug
| 产品编号 | bs-12542P |
| 英文名称 | ATF5 Antibody Blocking Peptide |
| 中文名称 | 活化转录因子5封闭多肽 |
| 英文别名 | Activating transcription factor 5 alpha/beta; Activating transcription factor 5; Activating transcription factor X; AFTA; ATF 5; ATF 7; ATF7; ATFX; BZIP protein ATF7; cAMP dependent transcription factor ATF 5; cAMP dependent transcription factor ATF5; Cyclic AMP dependent transcription factor ATF 5; Cyclic AMP dependent transcription factor ATF5; FLJ34666; HMFN0395; MGC102397; NAP1; NRIF3 associated protein; ODA 10; Transcription factor ATFx; Transcription factor like protein ODA 10; Transcription factor like protein ODA10; ATF5_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Co-factors Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > Leucine Zipper |
| 亚基 | Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2. Interacts with CDC34. |
| 亚细胞定位 | Cytoplasmic and Nuclear |
| 翻译后修饰 | Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. |
| 相似性 | Belongs to the bZIP family. Contains 1 bZIP (basic-leucine zipper) domain. |
| 功能 | ATF5 or Activating transcription factor 5, binds to cAMP inducible promoters and is involved in gene transcription. This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. ATF5 plays a role in inhibition of nerve growth factor induced neuronal outgrowth and regulation of neurogenesis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Eukaryotic gene transcription is regulated by sequence-specific transcription factors that bind modular cis acting promoter and enhancer elements. The ATF/CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The best characterized members of this gene family include CREB-1, CREB-2 (also designated ATF-4), CRE-BPa, LZIP (also designated CREB3 and Luman), CREM-1, CREM-2, ATF-1, ATF-2, ATF-3, ATF-5, ATF-6 and ATF-7. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. ATF-5 (ATFx), which can localize to the cytoplasm or the nucleus, binds DNA as a dimer. It interacts with CCND3 and PTP4A1. |
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ATF5 Antibody Blocking Peptide(bs-12542P)-500ug
￥880
