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- Bioss
- bs-11235P
- 2025年10月16日
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500ug
| 产品编号 | bs-11235P |
| 英文名称 | GRK6 Antibody Blocking Peptide |
| 中文名称 | G蛋白偶联受体激酶6封闭多肽 |
| 英文别名 | GRK 6; GRK-6; G protein coupled receptor kinase 6; G protein coupled receptor kinase GRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; G-protein-coupled receptor kinase 6; Gprk6; Grk6; GRK6_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Heart > Hypertrophy Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > GPCR Kinases Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Membrane; Lipid-anchor. |
| 组织特异性 | Widely expressed. |
| 翻译后修饰 | It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. |
| 相似性 | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain. |
| 功能 | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamin receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of Beta-adrenergic receptor kinase: GRK 2 (Beta ARK, Beta ARK1) and GRK 3 (Beta ARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state. |
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GRK6 Antibody Blocking Peptide(bs-11235P)-500ug
￥880
