MAFG Antibody Blocking Peptide(bs-18615P)-500ug

MAFG Antibody Blocking Peptide

(bs-18615P)-500ug
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  • bs-18615P
  • 2025年10月16日
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    北京博奥森生物技术有限公司
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      500ug

    产品编号bs-18615P
    英文名称MAFG Antibody Blocking Peptide
    中文名称转录因子MAFG封闭多肽
    英文别名AA545192; Basic leucine zipper transcription factor MafG; C630022N07Rik; hMAF; MAFG; MAFG v maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian); MAFG_HUMAN; MGC13090; MGC20149; RP23 84C12.9; Transcription factor MafG; V maf musculoaponeurotic fibrosarcoma oncogene homolog G; V-maf musculoaponeurotic fibrosarcoma oncogene homolog G.
    纯化方法HPLC
    研究领域

    Cell Biology > Other Antibodies > Oxidative Stress

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > Leucine Zipper

    Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription

    Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

    Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress

    亚细胞定位Nucleus.
    组织特异性Highly expressed in skeletal muscle. Also expressed in heart and brain.
    翻译后修饰Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
    Sumoylation at Lys-14 is required for active transcriptional repression.
    相似性Belongs to the bZIP family. Maf subfamily.
    Contains 1 bZIP domain.
    功能Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+).
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

     

     

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