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- Bioss
- bs-11217P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11217P |
| 英文名称 | MTMR14 Antibody Blocking Peptide |
| 中文名称 | 肌管素相关蛋白14封闭多肽 |
| 英文别名 | C3orf29; Egg derived tyrosine phosphatase homolog; FLJ11546; FLJ22405; FLJ46453; FLJ90311; HCV NS5A transactivated protein 4 splice variant A binding protein 1; HCV NS5A-transactivated protein 4 splice variant A-binding protein 1; hJumpy; jumpy; MTMR 14; MTMR14; MTMR-14; MTMRE_HUMAN; Myotubularin related protein 14; Myotubularin-related protein 14; NS5ATP4ABP1. |
| 纯化方法 | HPLC |
| 研究领域 | Microbiology > Interspecies Interaction > Host Virus Interaction Signal Transduction > Signaling Pathway > Lipid Signaling > Lipid Phosphatases |
| 亚基 | Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. |
| 亚细胞定位 | Cytoplasm. Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus. |
| 组织特异性 | Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas. |
| 相似性 | Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. |
| 功能 | Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Myotubularin-related protein 14 (MTMR14), also known as Jumpy, is a myotubularin-related phosphoinositol-3-phosphate (PI3P) phosphatase (1). Mutations in the MTMR14 gene have been associated with centronuclear myopathy (1). MTMR14 deficiency in mice leads to altered calcium homeostasis and muscle disorders (2). MTMR14 has also been shown to play a role in autophagy, a process that is highly regulated by phosphatidylinositides through the type III PI3K, Vps34 (3). MTMR14 was localized to autophagic isolation membranes and early autophagosomes (3). In these studies, MTMR14 inhibited autophagy and mutations of MTMR14 associated with centronuclear myopathy were also defective in autophagy inhibition. In zebrafish, MTMR14 knockdown was shown to increase the number of autophagosomes, suggesting that its activity is associated with an inhibition of autophagy (4). |
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MTMR14 Antibody Blocking Peptide(bs-11217P)-500ug
￥880
