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- Bioss
- bs-18602P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-18602P |
| 英文名称 | MACROD1 Antibody Blocking Peptide |
| 中文名称 | MACROD1蛋白封闭多肽 |
| 英文别名 | LRP16; MACD1_HUMAN; MACRO domain containing 1; MACRO domain-containing protein 1; Macrod1; O-acetyl-ADP-ribose deacetylase MACROD1; Protein LRP16. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Growth factors > Hormones Cancer > Signal transduction > Nuclear signaling > NFkB pathway Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > NFkB pathway Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Co-activators/co-repressors Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Estrogen Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Testosterone Signal Transduction > Growth Factors/Hormones > Hormones Signal Transduction > Signaling Pathway > Nuclear Signaling > NFkB Pathway Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Co-activators/co-repressors Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Estrogen Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Testosterone |
| 亚基 | Interacts with ESR1; Interacts in a manner that is estrogen independent but is enhanced by estrogen. Interacts (via macro domain) with AR. |
| 亚细胞定位 | Nucleus. |
| 相似性 | Contains 1 Macro domain. |
| 功能 | Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. |
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