- ￥880
- Bioss
- bs-18601P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-18601P |
| 英文名称 | LZTS2 Antibody Blocking Peptide |
| 中文名称 | 亮氨酸拉链抑癌蛋白2封闭多肽 |
| 英文别名 | hLZTS2; KIAA1813; LAPSER1; Leucine zipper putative tumor suppressor 2; LZTS2; LZTS2_HUMAN; OTTHUMP00000020289; Protein LAPSER1; RP11-108L7.8. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis. |
| 组织特异性 | Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon. |
| 相似性 | Belongs to the LZTS2 family. |
| 功能 | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | LAPSER1 is a member of the LZTS family. Due to its deletion in multiple cancers, including prostate tumors, LAPSER1 is purported to be a tumor suppressor. In cancer cell lines, the overexpression of LAPSER1 can lead to growth inhibition and colony-forming efficiency. LAPSER1 is highly expressed in testis and prostate, but can be detected at lower levels in spleen, thymus, uterus, small intestine and colon. LAPSER1 colocalizes with ?tubulin, MKLP-1 and p80 katanin. LAPSER1 is involved in cytokinesis. The disruption of LAPSER1, which is accompanied by the mislocalization of p80 katanin, results in malformation of the central spindle. This is a potential impetus for carcinogenesis. |
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LZTS2 Antibody Blocking Peptide(bs-18601P)-500ug
￥880
