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- bs-2377P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-2377P |
| 英文名称 | CNR2 Antibody Blocking Peptide |
| 中文名称 | 钙粘蛋白相关的神经受体2封闭多肽 |
| 英文别名 | Cannabinoid receptor 2; Cannabinoid Receptor II; Cannabinoid receptor 2 macrophage; CB 2; CB-2; CB2; CNR2; CB2R; CNRII; CNR-2; CNR 2; CX 5; CX5; CNR2_HUMAN. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cell membrane. Cell projection, dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons. |
| 组织特异性 | Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level). |
| 翻译后修饰 | Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of Marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of Marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]. |
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CNR2 Antibody Blocking Peptide(bs-2377P)-500ug
￥880
