- ￥1500 - 2500
- Bioss
- Y-0198P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug/1mg
| 规格： | 500ug | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥2500.0 |
| 产品编号 | Y-0198P |
| 英文名称 | Nogo-66 1-40 (NEP 1-40) Peptide |
| 中文名称 | Nogo-66 (1-40)多肽 |
| 英文别名 | Nogo-66(1-40) antagonist peptide; NEP 1-40 peptide; Reticulon-4; Neurite outgrowth inhibitor; Nogo protein; Foocen; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 理论分子量 | 4.622 |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent. Sequence: Acetyl-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-Amide MW:4622.35 |
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Nogo-66 1-40 (NEP 1-40) Peptide(Y-0198P)-500ug/1mg
￥1500 - 2500
