- ￥880
- Bioss
- bs-2374P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-2374P |
| 英文名称 | TAP2 Antibody Blocking Peptide |
| 中文名称 | ATP结合转运因子2封闭多肽 |
| 英文别名 | ABC18; ABCB3; Peptide supply factor 2; Peptide transporter PSF2; Peptide transporter TAP2; PSF2; RING 11; TAP 2; Transporter 2 ATP binding cassette sub family B. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Trafficking > Chaperones > Other Chaperones Signal Transduction > Protein Trafficking > ER Proteins Tags & Cell Markers > Subcellular Markers > Organelles > ER |
| 亚基 | Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a. |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 相似性 | Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding. |
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TAP2 Antibody Blocking Peptide(bs-2374P)-500ug
￥880
