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- Bioss
- bs-23737P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-23737P |
| 英文名称 | TNFRSF6B Antibody Blocking Peptide |
| 中文名称 | 诱捕受体3封闭多肽 |
| 英文别名 | DcR3; Decoy Receptor 3; Decoy receptor for Fas ligand; DJ583P15.1.1; M68; OTTHUMP00000031583; TNF6B_HUMAN; TNFRSF6B; TR6; Tumor necrosis factor receptor superfamily member 6B; M68; Tumor necrosis factor receptor superfamily member 6b decoy; UNQ186/PRO212. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis > Receptors > Decoy Receptors Cell Biology > Apoptosis > Receptors > Decoy Receptors Immunology > Innate Immunity > Cytokines > Necrosis Factors |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. |
| 相似性 | Contains 4 TNFR-Cys repeats. |
| 功能 | Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively. Unlike DcR1and DcR2, DcR3 is a soluble rather than a membraneassociated molecule. DcR3 binds to FasL and LIGHT andinhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and coloncarcinomas and in some normal tissues. |
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TNFRSF6B Antibody Blocking Peptide(bs-23737P)-500ug
￥880
