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- bs-1499P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-1499P |
| 英文名称 | SUMO1 Antibody Blocking Peptide |
| 中文名称 | 类泛素蛋白1封闭多肽 |
| 英文别名 | small ubiquitin-related modifier 1; GAP modifying protein 1; GAP-modifying protein 1; GMP 1; GMP1; PIC 1; PIC1; SENP2; Sentrin 1; Sentrin; Small ubiquitin related modifier 1; SMT3; SMT3 homolog 3; SMT3 suppressor of mif two 3 homolog 1; SMT3C; SMT3H3; Sumo1; Ubiquitin homology domain protein PIC1; Ubiquitin Like 1; Ubiquitin like protein SMT3C; Ubiquitin like protein UBL1; Ubiquitin-like protein UBL1; UBL 1; UBL1; SUMO1_HUMAN; SUMO-1;Ubiquitin-like protein SMT3C; Smt3C. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Autophagy > APG gene products Cardiovascular > Heart > Autophagy > APG gene products Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Sumo Epigenetics and Nuclear Signaling > ChIP assays > ChIP antibodies Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy > APG gene products |
| 亚基 | Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Interacts with PARK2. Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52. Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25. |
| 亚细胞定位 | Nucleus membrane. Nucleus speckle. Cytoplasm. Note=Recruited by BCL11A into the nuclear body. |
| 翻译后修饰 | Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
Polymeric SUMO1 chains undergo polyubiquitination by RNF4. |
| 相似性 | Belongs to the ubiquitin family. SUMO subfamily. Contains 1 ubiquitin-like domain. |
| 功能 | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] |
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SUMO1 Antibody Blocking Peptide(bs-1499P)-500ug
￥880
