- ￥880
- Bioss
- bs-23708P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-23708P |
| 英文名称 | Myocardin Antibody Blocking Peptide |
| 中文名称 | 促血管平滑肌细胞分化因子封闭多肽 |
| 英文别名 | MYCD; MYCD_HUMAN; Myocardin; Myocd. |
| 纯化方法 | HPLC |
| 亚基 | Homodimer. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts with MLLT7/FOXO4. Interacts (via C-terminal) with EP300 (via the CREB-binding domain). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle. |
| 翻译后修饰 | Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity. |
| 相似性 | Contains 3 RPEL repeats. Contains 1 SAP domain. |
| 功能 | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Transcriptional factor that uses the canonical single or multiple CArG boxes DNA sequence. Binds CArG boxes only in the presence of serum response factor (SRF). Acts as a cofactor of SRF and modulates SRF-target genes. Regulates the expression of a set of cardiac and smooth muscle-specific genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. |
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Myocardin Antibody Blocking Peptide(bs-23708P)-500ug
￥880
