- ￥880
- Bioss
- bs-12485P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12485P |
| 英文名称 | ANAPC2 Antibody Blocking Peptide |
| 中文名称 | 腺瘤性结肠息肉病蛋白2封闭多肽 |
| 英文别名 | Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APCL; APC2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Cell Division > Other cell division antibodies Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > APC/C |
| 亚基 | Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2. |
| 亚细胞定位 | Cell Membrane, Cytoplasmic and Golgi Apparatus |
| 组织特异性 | Widely expressed (at protein level). Specifically expressed in the CNS. |
| 相似性 | Belongs to the adenomatous polyposis coli (APC) family. Contains 6 ARM repeats. |
| 功能 | APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner’s syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. b-catenin and g-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin. |
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ANAPC2 Antibody Blocking Peptide(bs-12485P)-500ug
￥880
