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- bs-15076P
- 2025年10月16日
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500ug
| 产品编号 | bs-15076P |
| 英文名称 | CHTOP Antibody Blocking Peptide |
| 中文名称 | 1号染色体开放阅读框77封闭多肽 |
| 英文别名 | Chromatin target of PRMT1 protein; Chromosome 1 open reading frame 77; CHTOP; CHTOP_HUMAN; DKFZp547E1010; FOP; Friend of PRMT1 protein; MGC131924; MGC86949; OTTHUMP00000035122; OTTHUMP00000035123; Pp7704; RP1 178F15.2; Small arginine- and glycine-rich protein; Small protein rich in arginine and glycine; SRAG. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Estrogen Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Estrogen |
| 亚基 | Interacts with PRMT1 and PRMT5. Interacts with the 5FMC complex; the interaction is methylation-dependent. Interacts with FYTTD1, SET and PRC1 complex members CBX4, RNF2 and PHC2; the interactions are methylation-independent. Interacts with ZNF148 (By similarity). |
| 亚细胞定位 | Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm (By similarity). Note=Mostly associated with facultative heterochromatin (By similarity). |
| 组织特异性 | Expressed in an erythroid progenitor cell line derived from peripheral blood. |
| 翻译后修饰 | Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5 (By similarity). |
| 功能 | Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | C1orf77, also known as Friend of PRMT1 protein, is a 248 amino acid protein that plays an essential role in the ligand-dependent activation of estrogen receptor target genes. C1orf77 is tightly associated with chromatin and is modified by both asymmetric and symmetric arginine methylation. Depletion of C1orf77 results in almost complete block of estradiol-induced promter occupancy by the estrogen receptor. Also, complete knockdown of C1orf77 mRNA in adult erythroid progenitors stongly induces fetal hemoglobin, suggesting that C1orf77 is a critical modulator of γ-globin gene expression. There are two isoforms of C1orf77 that are produced as a result of alternative splicing events. The gene encoding C1orf77 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. |
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CHTOP Antibody Blocking Peptide(bs-15076P)-500ug
￥880
