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- bs-12447P
- 2025年10月16日
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500ug
| 产品编号 | bs-12447P |
| 英文名称 | phospho-ADAM17 (Thr735) Antibody Blocking Peptide |
| 中文名称 | 磷酸化CD156b封闭多肽 |
| 英文别名 | ADAM17 (phospho T735); p-ADAM17 (phospho T735); p-CD156b(phospho T735); A disintegrin and metalloproteinase domain 17; ADAM 17; ADAM metallopeptidase domain 17; ADAM17 protein; CD 156b; CD156b; CD156b antigen; CSVP; MGC71942; Snake venom like protease; TACE; TNF alpha convertase; TNF alpha converting enzyme; Tumor Necrosis Factor Alpha Converting Enzyme; A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme). |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cancer Metabolism > Response to hypoxia Cancer > Invasion/microenvironment > ECM > Extracellular matrix > ADAM protein family Cancer > Signal transduction Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Metalloprotease > ADAMs Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Metabolism > Types of disease > Cancer Metabolism > Types of disease > Neurodegenerative disease Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Signal Transduction > Adapters > Transmembrane Stem Cells > Signaling Pathways > Notch > Secreted |
| 亚基 | Interacts with MAD2L1, MAPK14 and MUC1. |
| 亚细胞定位 | Membrane. |
| 组织特异性 | Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney. |
| 相似性 | Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. |
| 功能 | Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq]. |
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