- ￥880
- Bioss
- bs-12435P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12435P |
| 英文名称 | FRAT2 Antibody Blocking Peptide |
| 中文名称 | GSK-3结合蛋白FRAT2封闭多肽 |
| 英文别名 | Frequently rearranged in advanced T-cell lymphomas 2 antibodyGSK-3 binding protein FRAT2; FRAT2_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Binds GSK-3 and prevents GSK-3-dependent phosphorylation. |
| 相似性 | Belongs to the GSK-3-binding protein family. |
| 功能 | Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins. |
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FRAT2 Antibody Blocking Peptide(bs-12435P)-500ug
￥880
