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- Bioss
- bs-13704P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-13704P |
| 英文名称 | Uroplakin Ia Antibody Blocking Peptide |
| 中文名称 | 尿路上皮特异蛋白1a封闭多肽 |
| 英文别名 | UPK1A_HUMAN; Uroplakin-1a; UP1a; Tetraspanin-21; Tspan-21; Uroplakin Ia; UPIa; UPKa. |
| 纯化方法 | HPLC |
| 亚基 | Homodimer; disulfide-linked. Interacts with uroplakin-2 (UPK2). |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 组织特异性 | High expression restricted to ureteric urothelium (most superficial cells); low expression in prostate. Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies. |
| 相似性 | Belongs to the tetraspanin (TM4SF) family. |
| 功能 | Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response. |
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Uroplakin Ia Antibody Blocking Peptide(bs-13704P)-500ug
￥880
