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- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-0764P |
| 英文名称 | CCK8 Antibody Blocking Peptide |
| 中文名称 | 胆囊收缩素8封闭多肽 |
| 英文别名 | CCK 8; CCK; CCK8; CCK-8; Cholecystokinin 8; Cholecystokinin;Cholecystokinin preproprotein; Cholecystokinin8; Cholecystokinins precursor; MGC117187; Procholecystokinin precursor; CCKN_HUMAN. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Metabolism > Types of disease > Obesity Signal Transduction > Growth Factors/Hormones > Hormones |
| 亚基 | Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | The shortest form (CCK8) is predominantly found in the brain, whereas the larger ones are found in the intestine. |
| 翻译后修饰 | The precursor is cleaved by proteases to produce a number of active cholecystokinins. |
| 相似性 | Belongs to the gastrin/cholecystokinin family. |
| 功能 | Cholecystokinin (CCK) is one of the most important hormone regulators of the digestive process. The peptide is concentrated in the proximal small intestine (CCK cells) and is secreted into the blood in response to the ingestion of proteins and fats, where its actions include the stimulation of pancreatic secretion, the modulation of insulin output, the regulation of gastric emptying, and gallbladder contraction. In the central nervous system CCKergic fibres are widespread, being particularly abundant in the cerebral cortex. In some mesolimbic neurons projecting to the nucleus accumbens, CCK is colocalised with dopamine and it has been suggested that CCK might facilitate the function of dopamine in events such as stimulusreward associative behaviour. Secretion of CCK from the murine tumour cell line STC1 has been shown to be stimulated by pituitary adenylate cyclase activating protein (PACAP) and has raised the possibility that PACAP may function as a neuromodulator of CCK release from gut endocrine cells in vivo. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]. |
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文献和实验[IF={{ 6.162 }}] {Zhang W et al. Cinnamaldehyde Enhances Antimelanoma Activity through Covalently Binding ENO1 and Exhibits a Promoting Effect with Dacarbazine. Cancers (Basel). 2020 Jan 29;12(2). pii: E311.} {Other} {}
[IF={{ 4.3 }}] {Sendaer Hailati. et al. Searching for Hub Genes of Quince–Basil Co-Administration Against Atherosclerosis Using Bioinformatics Analysis and Experimental Validation. PHARMACEUTICALS-BASE. 2024 Nov;17(11):1433} {} {}
[IF={{ 14.9 }}] {Yuan Zhiyao. et al. Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress. INT J ORAL SCI. 2024 May;16(1):1-10} {Other} {}
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