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- Bioss
- bs-17585P
- 2025年10月16日
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500ug
| 产品编号 | bs-17585P |
| 英文名称 | phospho-RBL2 (Ser952) Antibody Blocking Peptide |
| 中文名称 | 磷酸化视网膜母细胞瘤相关蛋白p130封闭多肽 |
| 英文别名 | Rb2 p130 (phospho S952); p-Rb2 p130 (phospho S952); p130; PRB2; Rb2; RBL2; RBR2; Retinoblastoma like 2; Retinoblastoma like protein 2. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors > Rb family Cell Biology > Cell Cycle > Cell Cycle Inhibitors > Rb Epigenetics and Nuclear Signaling > Cell cycle > Cell Cycle Inhibitors > Rb |
| 亚基 | Interacts with AATF. Interacts with SUV420H1, SUV420H2 and USP4. |
| 亚细胞定位 | Nucleus. |
| 翻译后修饰 | During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis. |
| 相似性 | Belongs to the retinoblastoma protein (RB) family. |
| 功能 | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | p130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107 (collectively known as pocket proteins) and is known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors. |
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phospho-RBL2 (Ser952) Antibody Blocking Peptide(bs-17585P)-500ug
￥1080
