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- Bioss
- bs-17566P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-17566P |
| 英文名称 | OTUD5 Antibody Blocking Peptide |
| 中文名称 | 去泛素酶A封闭多肽 |
| 英文别名 | Deubiquinating enzyme A; Deubiquitinating enzyme A; DKFZp761A052; DUBA; MGC104871; OTTHUMP00000025821; OTU domain containing 5; OTU domain containing protein 5; OTU domain-containing protein 5; OTUD 5; otud5; OTUD5_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Deubiquitination Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Other proteases Epigenetics and Nuclear Signaling > Ubiquitin & Ubiquitin Like Modifiers > Deubiquitination |
| 亚基 | Interacts with TRAF3. |
| 组织特异性 | Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. |
| 翻译后修饰 | Phosphorylation at Ser-177 is required for deubiquitinating activity. |
| 相似性 | Belongs to the peptidase C85 family. Contains 1 OTU domain. |
| 功能 | Negative regulator of innate immune system. Has deubiquitinating activity that is directed towards 'Lys-63'-linked polyubiquitin chains. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008] |
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OTUD5 Antibody Blocking Peptide(bs-17566P)-500ug
￥880
