- ￥880
- Bioss
- bs-13675P
- 2025年10月16日
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500ug
| 产品编号 | bs-13675P |
| 英文名称 | PIK3AP1 Antibody Blocking Peptide |
| 中文名称 | 磷酸肌醇3激酶接头蛋白1封闭多肽 |
| 英文别名 | B cell adaptor protein; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1; BCAP; BCAP_HUMAN; OTTHUMP00000020175; OTTHUMP00000020176; Phosphoinositide 3 kinase adaptor protein 1; Phosphoinositide 3-kinase adapter protein 1; PIK3AP1; RP11-34E5.3. |
| 纯化方法 | HPLC |
| 亚基 | Homooligomer (By similarity). Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase. Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1. May interact with MYD88 and TIRAP (By similarity). |
| 亚细胞定位 | Cytoplasm. Cell membrane. |
| 组织特异性 | Expressed in natural killer (NK) cells. |
| 翻译后修饰 | Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK (By similarity). Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation (By similarity). Phosphorylated on tyrosine residues in C-terminus region by ABL1 and V-abl. |
| 相似性 | Contains 1 DBB domain. |
| 功能 | Involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. Seems to have a complementary role with CD19 in PI3K activation (By similarity). May be involved in the survival of mature B cells via activation of REL. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | B cell adaptor for phosphoinositide 3-kinase (BCAP) is a tyrosine kinase substrate that bridges B cell receptor (BCR) associated kinases to the PIK3 pathway. Syk, Btk or Lyn-dependent tyrosine phosphorylation of BCAP, provides binding sites for the p85 subunit of PIK3. BCAP mRNA is present in mouse spleen, thymus, liver, lung, macrophage and B cell lines. Human BCAP maps to chromosome 10q24.2. |
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PIK3AP1 Antibody Blocking Peptide(bs-13675P)-500ug
￥880
