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- Bioss
- bs-43567P
- 2025年10月16日
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- 规格：
100ug/500ug/20ug
| 规格： | 100ug | 产品价格： | ￥2280.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥6880.0 |
| 规格： | 20ug | 产品价格： | ￥680.0 |
| 产品编号 | bs-43567P |
| 英文名称 | Recombinant human DR4 protein, C-His-Avi (HEK293) |
| 中文名称 | 重组人死亡受体4蛋白 |
| 英文别名 | Tumor necrosis factor receptor superfamily member 10A; Apo 2; Apo2; CD 261; CD261; CD261 antigen; Cytotoxic ligand TRAIL receptor; Cytotoxic TRAIL receptor; Death receptor 4; DR 4; DR4; MGC9365; NF related apoptosis-inducing ligand receptor 1; T10A; TNF related apoptosis inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR 1; TRAILR1; Tumor necrosis factor receptor superfamily member 10A precursor; TR10A_HUMAN; Recombinant human DR4 protein, C-His-Avi (HEK293) |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 24.7 |
| 储存液 | 10mM PBS (pH7.4). |
| 研究领域 | Cardiovascular > Angiogenesis > Endothelial Cell Markers Cell Biology > Apoptosis > Receptors > Death Receptors Immunology > Innate Immunity > Cytokines > TNF Superfamily |
| 亚基 | Can interact with TRADD and RIPK1. Interacts with ARAP1. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells. |
| 相似性 | Contains 1 death domain. Contains 3 TNFR-Cys repeats. |
| 功能 | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008] |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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Recombinant human DR4 protein, C-His-Avi (HEK293)(bs-43567P)-100ug/500ug/20ug
￥680 - 6880
