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- Bioss
- bs-1030P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-1030P |
| 英文名称 | HMGA1 Antibody Blocking Peptide |
| 中文名称 | 高迁移率族蛋白A1封闭多肽 |
| 英文别名 | HMG-I; HMG-Y; High mobility group AT-hook 1; HMG-I/HMG-Y; HMG-R; HMGA 1a; HMGA 1b; HMGA1; HMGI; HMGI/Y; HMGIY; HMGY; MGC12816; MGC4242; MGC4854; HMGA1_HUMAN; High mobility group protein HMG-I/HMG-Y; HMG-I(Y); AltName: Full=High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein R. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Tumor biomarkers Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > DNA / RNA binding Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > Base Excision Repair Epigenetics and Nuclear Signaling > Transcription > Transcription Factors Microbiology > Interspecies Interaction > Host Virus Interaction |
| 亚基 | Interacts with HIPK2 (By similarity). Interacts with HIV-1 pre-integration complex. |
| 亚细胞定位 | Nucleus. Chromosome. |
| 翻译后修饰 | Constitutively phosphorylated on two or three sites. Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.
HMG-Y is not methylated. Methylation at Arg-58 is mutually exclusive with methylation at Arg-60. |
| 相似性 | Belongs to the HMGA family.
Contains 3 A.T hook DNA-binding domains. |
| 功能 | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | HMGA1 (HMGI/Y; high mobility group AT-hook 1) is a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. There are two splice isoforms of HMGA1 - the full length HMGA1a/HMGI and the shortened form HMGA1b/HMGY. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. HMGA1 is frequently acetylated and is found in the nucleus. Interacts with HIV-1 pre-integration complex. |
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HMGA1 Antibody Blocking Peptide(bs-1030P)-500ug
￥880
