- ￥880
- Bioss
- bs-11066P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11066P |
| 英文名称 | DOK6 Antibody Blocking Peptide |
| 中文名称 | 胞浆接头蛋白Dok6封闭多肽 |
| 英文别名 | Docking protein 5; Docking protein 5 like; Docking protein 6; DOK 6; DOK6; DOK-6; DOK5; DOK 5; DOK-5; DOK5L; Downstream of tyrosine kinase 6; HsT3226; MGC20785; Protein dok 5; DOK6_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Adapters > Transmembrane Signal Transduction > Growth Factors/Hormones > Insulin / Insulin-like |
| 亚基 | Interacts via its PTB domain with phosphorylated RET. |
| 组织特异性 | Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. |
| 翻译后修饰 | On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase. |
| 相似性 | Belongs to the DOK family. Type B subfamily. Contains 1 IRS-type PTB domain. Contains 1 PH domain. |
| 功能 | DOK6 (docking protein 6) is a novel member of the DOK4/5 subclass of the p62 DOK family of intracellular adaptor molecules. DOK6 is highly expressed in the developing central nervous system and is co expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull down assays using the DOK6 phosphotyrosine binding (PTB) domain and GDNF activated Ret indicate that DOK6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of DOK6 predominantly through a Src dependent mechanism, indicating that DOK6 is a substrate of the Ret Src signaling pathway. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection. |
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DOK6 Antibody Blocking Peptide(bs-11066P)-500ug
￥880
