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- Bioss
- bs-11063P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11063P |
| 英文名称 | PKP2 Antibody Blocking Peptide |
| 中文名称 | 桥粒斑菲素蛋白2封闭多肽 |
| 英文别名 | ARVD 9; ARVD-9; ARVD9; PKP 2; PKP2; PKP-2; Plakophilin-2. Plakophilin2; PKP2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Angiogenesis > Adhesion / ECM > Extracellular Matrix Neuroscience > Cell Adhesion Proteins > ECM Proteins Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > Structures > Desmosomes |
| 亚基 | Interacts with DSC2. |
| 亚细胞定位 | Nucleus. Cell junction, desmosome.Note=Nuclear and associated with desmosomes. |
| 组织特异性 | Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the beta-catenin family. Contains 8 ARM repeats. |
| 功能 | May play a role in junctional plaques. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains, and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin-1 mediates increases in desmosomal protein content, desmosome assembly, and regulation of cell migration. Plakophilin-2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin-3 plays a role in both desmosome-dependent adhesion and signaling pathways. Plakophilin-4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function. |
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PKP2 Antibody Blocking Peptide(bs-11063P)-500ug
￥880
