- ￥880
- Bioss
- bs-17540P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-17540P |
| 英文名称 | HLA DOB Antibody Blocking Peptide |
| 中文名称 | 组织相容性抗原DOB封闭多肽 |
| 英文别名 | DO beta chain; DOB; DOB_HUMAN; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen DO beta chain; HLA-DOB; Major histocompatibility complex class II DO beta; Major histocompatibility complex class II DO beta chain; MHC class II antigen DOB. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Endosome membrane. Lysosome membrane. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER. |
| 相似性 | Belongs to the MHC class II family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. |
| 功能 | Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B cells. Modifies peptide exchange activity of HLA-DM. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
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HLA DOB Antibody Blocking Peptide(bs-17540P)-500ug
￥880
