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- Bioss
- bs-12392P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12392P |
| 英文名称 | TLE5 Antibody Blocking Peptide |
| 中文名称 | gp130结合蛋白GAM封闭多肽 |
| 英文别名 | Aes 1; Amino-terminal enhancer of split; Aes 2; aes; AES_HUMAN; Aes1; Aes2; Amino Enhancer of Split; Amino terminal enhancer of split; Amino-terminal enhancer of split; Esp 1; Esp1; Gp130 associated protein GAM; Gp130-associated protein GAM; GRG 5; GRG; GRG protein; GRG5; Protein ESP 1; Protein ESP1; Protein GRG; TLE 5; TLE5. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Co-factors Stem Cells > Signaling Pathways > Notch > Nuclear Stem Cells > Signaling Pathways > Wnt > Nuclear |
| 亚基 | Homooligomer and heterooligomer with other family members. Binds TCF7 (By similarity). Binds the NF-kappa-B subunit RELA. Interacts with PHF12. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver. |
| 翻译后修饰 | Ubiquitinated by XIAP/BIRC4. |
| 相似性 | Belongs to the WD repeat Groucho/TLE family. |
| 功能 | Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TLE5 is a 197 amino acid nuclear protein that belongs to the TLE family. Expressed predominately in fetal brain, liver, lung, heart and kidney and in adult muscle, TLE5 functions as either a homooligomer or a heterooligomer with other TLE family members and, through this association, dominantly represses the expression of TLE genes. In addition, TLE5 can repress NFkB-regulated gene expression and is thought to play an important role in initiating and maintaining cell differentiation events. Two isoforms of TLE5 exist due to alternative splicing events. |
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TLE5 Antibody Blocking Peptide(bs-12392P)-500ug
￥880
