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- Bioss
- bs-11059P
- 2025年10月16日
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500ug
| 产品编号 | bs-11059P |
| 英文名称 | NTN3 Antibody Blocking Peptide |
| 中文名称 | 轴突生长诱导因子3封闭多肽 |
| 英文别名 | NET3_HUMAN; Netrin-2-like protein; Netrin3; Netrin-3; Netrin 3; NTN2L; NTN3. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Adhesion Proteins > ECM Proteins Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins |
| 亚细胞定位 | Secreted; extracellular space; extracellular matrix. |
| 组织特异性 | Spinal cord. |
| 相似性 | Contains 3 laminin EGF-like domains. Contains 1 laminin N-terminal domain. Contains 1 NTR domain. |
| 功能 | Netrins control guidance of CNS commissural axons and peripheral motor axons. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins as the cells are repelled, rather than attracted, by the netrin gradient. Neogenin serves as the primary guidance receptor for netrin-3. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or repel commissural axons at a distance. Netrin-3 proteins are associated with the axon fibers projecting from motor neurons and from neurons within sympathetic and sensory ganglia, suggesting that netrin-3 may be involved in pathfinding and fasciculation of axon projection. Neogenin serves as the primary guidance receptor for netrin-3. During peripheral nerve development, high netrin-3 expression has been detected in mesenchymal cells, sensory ganglia and muscles. In humans, the gene encoding for the netrin-3 protein is localized to chromosome 16p13.3. |
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NTN3 Antibody Blocking Peptide(bs-11059P)-500ug
￥880
