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- Bioss
- bs-12365P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-12365P |
| 英文名称 | SIX2 Antibody Blocking Peptide |
| 中文名称 | 转录因子同源框蛋白SIX2封闭多肽 |
| 英文别名 | Homeobox protein SIX2; OTTHUMP00000201649; Sine oculis homeobox (Drosophila) homolog 2; Sine oculis homeobox homolog 2; Sine oculis homeobox homolog 2 (Drosophila); SIX homeobox 2; Six2; SIX2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Organogenesis > Excretory system development > Kidney development Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families Stem Cells > Mesenchymal Stem Cells > Chondrogenesis |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Strongly expressed in skeletal muscle. |
| 相似性 | Belongs to the SIX/Sine oculis homeobox family. Contains 1 homeobox DNA-binding domain. |
| 功能 | May be involved in limb tendon and ligament development. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Six proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six2, Six4 (AREC3) and Six5 bind to the same DNA sequence, indicating that they may regulate the same target genes. Six1 and Six4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. Six1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. Six1 overexpression has been shown to abrogate the G2 cell cycle checkpoint. Six2 is highly expressed in fetal tissues but expression is limited in adult tissues. |
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SIX2 Antibody Blocking Peptide(bs-12365P)-500ug
￥880
