- ￥880
- Bioss
- bs-13629P
- 2025年10月16日
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500ug
| 产品编号 | bs-13629P |
| 英文名称 | CLIC2 Antibody Blocking Peptide |
| 中文名称 | 氯离子通道蛋白2封闭多肽 |
| 英文别名 | Chloride intracellular channel 2; Chloride intracellular channel protein 2; CLIC 2b; CLIC2; CLIC2_HUMAN; CLIC2b; MRXS32; OTTHUMP00000196471; XAP 121; XAP121. |
| 纯化方法 | HPLC |
| 研究领域 | Metabolism > Types of disease > Cancer Signal Transduction > Adapters > Transmembrane Signal Transduction > Metabolism > Plasma Membrane > Channels |
| 亚细胞定位 | Cytoplasm. Membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. |
| 组织特异性 | Detected in adult brain, heart, liver, lung, spleen, stomach and testis. Expressed in fetal liver and adult skeletal muscle. |
| 相似性 | Belongs to the chloride channel CLIC family. Contains 1 GST C-terminal domain. |
| 功能 | Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Chloride channels (CLCs) regulate cellular traffic of chloride ions, a critical component of all living cells. CLCs are involved in membrane potential stabilization, signal transduction, cell volume regulation and organic solute transport. The putative 247 amino acid protein chloride intracellular channel 2 (CLIC2), also designated XAP121, shares 60% identity with the CLIC1 protein and demonstrates expression in only fetal liver and adult skeletal muscle tissues. The CLIC2 gene maps to chromosome Xq28 and contains 6 exons. Because a direct association exists between a number of human chloride channel genes and a range of hereditary diseases, CLIC2 is a potential candidate for one of the many diseases linked to Xq28. The hereditary form of incontinentia pigmenti (IP2), for example, is a rare disorder characterized by abnormalities of the tissues and organs derived from the ectoderm and neuroectoderm that has been linked to Xq28 |
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CLIC2 Antibody Blocking Peptide(bs-13629P)-500ug
￥880
