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- Bioss
- bs-1360P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-1360P |
| 英文名称 | GADD45A Antibody Blocking Peptide |
| 中文名称 | 生长抑制DNA损伤基因45封闭多肽 |
| 英文别名 | Growth Arrest And DNA Damage Inducible Alpha; DNA Damage-Inducible Transcript 1 Protein; DDIT-1; GADD45; DDIT1; Growth Arrest And DNA Damage-Inducible Protein GADD45 Alpha; Growth Arrest And DNA-Damage-Inducible 45 Alpha; Growth Arrest And DNA-Damage-Inducible, Alpha; DNA Damage-Inducible Transcript-1; GA45A_HUMAN |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > Base Excision Repair |
| 亚基 | Interacts with MAPK14. Predominantly monomeric but also forms dimers and other oligomers as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely to compete with dimerization. |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the GADD45 family. |
| 功能 | In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53 dependent and independent mechanisms. |
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GADD45A Antibody Blocking Peptide(bs-1360P)-500ug
￥880
